Band Tension And The Great Southern Trendkill (1994–1996)

According to the Abbott brothers, frontman Phil Anselmo began behaving strangely and distanced himself from the band when they returned to the road in 1995. The rest of the band members first thought that Pantera's fame had gotten to Anselmo, but Anselmo cited back pain from years of intense performances as the reason for his erratic behavior. Anselmo attempted to subdue his pain through alcohol, but this, as he admits, was affecting his performances and "putting some worry into the band." Doctors predicted that with surgery, Anselmo's back problem could be corrected, but that the recovery time could be a year or more. Not wanting to spend that much time away from the band, Anselmo refused, and began using heroin as a painkiller.

Anselmo's on-stage remarks became notorious during this time. After stating at a Montreal concert that "rap music advocates the killing of white people," Anselmo denied accusations of racism, and later issued an apology, stating that he was drunk and that his remarks were a mistake.
In 1995, Down, one of Anselmo's many side projects, took off. Down was a supergroup consisting of Anselmo, three members of Crowbar—guitarist Kirk Windstein, bassist Todd Strange and drummer Jimmy Bower (also of Eyehategod)—and Corrosion of Conformity guitarist Pepper Keenan. Down's 1995 debut, NOLA, was a success, but shortly after the group members returned to their respective bands, leaving Down inactive for several years.

Pantera's next album, The Great Southern Trendkill (released May 22, 1996), came out during grunge rock's dominance and at the onset of rap metal. It is often considered Pantera's "overlooked" album. Phil Anselmo recorded the vocals for this release in Nine Inch Nails frontman Trent Reznor's studio in New Orleans while the rest of the band members recorded in Dallas, evidence of the continued distancing between Anselmo and the rest of the band. In comparison to the band's previous efforts, there was a heavier emphasis on vocal overdubbing in a somewhat "demonic" fashion. Drug abuse is a popular theme in Trendkill, as exemplified by tracks such as "Suicide Note Pt. I," "Suicide Note Pt. II" and "Living Through Me (Hell's Wrath)." Perhaps the most popular song from Trendkill is "Drag the Waters". "Drag the Waters" became the album's only music video, and likewise, the only track from the album to appear on the band's compilation album. Another Trendkill single, "Floods", achieved acclaim largely because of Darrell's complex guitar solo in the song, which ranked #15 on Guitar World magazine's list of the "100 Greatest Guitar Solos" of all-time.

In an episode of the short-lived Australian sex advice show "Sex Life," in a segment discussing what to make of a man's CD collection when first going back to his place, the host drew out a copy of "The Great Southern Trendkill" and referred to Pantera as "the loudest band in the world."