God Hates Us All (2001–2005)

After delays regarding remixing and artwork, including slip covers created to cover the original artwork as it was deemed "too graphic," God Hates Us All was released on September 11, 2001. The band received its first Grammy nomination for the lead track "Disciple," although the Grammy was awarded to Tool, for "Schism." The September 11th attack on America jeopardized the 2001 European tour Tattoo the Planet originally set to feature Pantera, Static X, Biohazard and Vision of Disorder. Dates were canceled or postponed due to flight restrictions, with a majority of bands deciding to withdraw, leaving Slayer and Static X remaining for the European leg of the tour. Pantera, Vision of Disorder and Biohazard were replaced by Cradle of Filth and other bands dependent on location Amorphis, In Flames, Moonspell, Children of Bodom, and Necrodeath. The Birmingham, England date on the tour though only featured Slayer, Biohazard, Cradle of Filth and Raging Speedhorn due to Static X pulling out over previous commitments, instead playing their scheduled dates in Germany. Drummer Bostaph left Slayer before Christmas in 2001, due to a chronic elbow injury which would hinder his ability to play. Slayer's "God Hates Us All" tour was unfinished so King contacted original drummer Lombardo, and asked if he would like to finish the remainder of the tour. Lombardo accepted the offer, and stayed as a permanent member.

Slayer toured playing Reign in Blood in its entirety throughout the fall of 2003, under the tour banner "Still Reigning". Their playing of the final song "Raining Blood" culminated with the band drenched in a rain of stage blood. Live footage of this was recorded at the Augusta Civic Center in Augusta, Maine, on July 11, 2004 and released on the 2004 DVD Still Reigning. The band also released War at the Warfield and a box set, Soundtrack to the Apocalypse featuring rarities, live CD and DVD performances and various Slayer paraphernalia.

From 2002 to 2004 the band performed over 250 tour dates, headlining major music festivals including H82k2, Summer tour, Ozzfest 2004 and a European tour with Slipknot. While preparing for the Download Festival in England, Metallica drummer Lars Ulrich was rushed to hospital with a mysterious illness, and was unable to perform. Metallica vocalist James Hetfield searched for volunteers at the last minute to replace Ulrich Lombardo and Slipknot drummer Joey Jordison volunteered, with Lombardo performing the songs "Battery" and "The Four Horsemen".